Tox!

All-in-one voice and text chat for gamers that’s free, secure, and works on both your desktop and phone. Stop paying for TeamSpeak servers and hassling with Skype.

Mumble was the first and is the most successful and wide spread free and open source software for VoIP. It was the first VoIP software to provide low-latency audio suitable for gaming, and at the same time was a pioneer in high audio quality at the same time.

Riot (formerly Vector) is an opensource interoperable app running on Web, iOS and Android. It is built around chat rooms, both public and private and provides messaging, filesharing, voice and video conferencing (beta on Android and web), integrations to tools like GitHub, Jira, Jenkins and much more soon. Vector is built on the Matrix.org open standard which provides bridges to other systems such as Slack, IRC and a lot more soon. One can use the hosted service or run their own. »

RetroShare is a open source cross-platform, private and secure decentralized communication system. It lets you to securely chat, share photos, videos, and more, using OpenPGP to authenticate peers and OpenSSL to encrypt all communication.

Adium is a free and open source instant messaging application for Mac OS X, written using Mac OS Xs Cocoa API, released under the GNU GPL and developed by the Adium team. Based on the libpurple protocol library, Adium can connect you to any number of messaging accounts on any combination of supported messaging services and then chat with other people using those services.

ChatSecure is a free and open source messaging app that features OTR encryption over XMPP. You can connect to your existing accounts on Facebook or Google, create new accounts on public XMPP servers(including via Tor), or even connect to your own server for extra security.

Threema is a new mobile messaging app that puts security first. With true end-to-end encryption, you can rest assured that only you and the intended recipient can read your messages.

Empathy is a messaging program which supports text, voice, video chat, and file transfers over many different protocols. You can tell it about your accounts on all those services and do all your chatting within one application.

Conversations is a privacy focused, open source XMPP Texting [Jabber] client for Android 4.0+ smart phones with wife-approved easy encryption [OTR, OMEMO, or GPG].