PyGTK!

PyQt is a set of Python bindings for Nokia's Qt application framework and runs on all platforms supported by Qt including Windows, MacOS/X and Linux. There are two sets of bindings: PyQt v4 supports Qt v4; and the older PyQt v3 supports Qt v3 and earlier. The bindings are implemented as a set of Python modules and contain over 300 classes and over 6,000 functions and methods.

wxWidgets is a C++ library that lets developers create applications for Windows, OS X, Linux and UNIX on 32-bit and 64-bit architectures as well as several mobile platforms including Windows Mobile, iPhone SDK and embedded GTK+. It has popular language bindings for Python, Perl, Ruby and many other languages. Unlike other cross-platform toolkits, wxWidgets gives its applications a truly native look and feel because it uses the platform's native API rather than emulating the GUI. It's also extensive, free, open-source and mature. Why not give it a try, like many others have? »

wxPython is a GUI toolkit for the Python programming language. It allows Python programmers to create programs with a robust, highly functional graphical user interface, simply and easily. It is implemented as a Python extension module (native code) that wraps the popular wxWidgets cross platform GUI library, which is written in C++.

Nana C++ Library takes aim at easy-to-use and portable library, it provides a GUI framework and threads for easy programming with modern C++ methods, such as traits, metaprogramming and other template technologies. http://sourceforge.net/p/nanapro/blog

The Fast, Light Toolkit (FLTK, pronounced fulltick) is a cross-platform graphical user interface (GUI) library developed by Bill Spitzak and others. Made to accommodate 3D graphics programming, it has an interface to OpenGL, but it is also suitable for general GUI programming.

Crazy Eddie's GUI (CEGUI) system is a graphical user interface C++ library. It was designed particularly for the needs of video games, but the library is usable for non-game tasks, such as applications and tools. It is designed for user flexibility in look-and-feel, as well as being adaptable to the user's choice in tools and operating systems.

gtkmm is the official C++ interface for the popular GUI library GTK+. Highlights include typesafe callbacks, and a comprehensive set of widgets that are easily extensible via inheritance. You can create user interfaces either in code or with the Glade User Interface designer, using Gtk::Builder. There's extensive documentation, including API reference and a tutorial.

The FOX toolkit is an open source, cross-platform widget toolkit, that is, a library of basic elements for building a graphical user interface (GUI).