IUP Portable User Interface!

wxWidgets is a C++ library that lets developers create applications for Windows, OS X, Linux and UNIX on 32-bit and 64-bit architectures as well as several mobile platforms including Windows Mobile, iPhone SDK and embedded GTK+. It has popular language bindings for Python, Perl, Ruby and many other languages. Unlike other cross-platform toolkits, wxWidgets gives its applications a truly native look and feel because it uses the platform's native API rather than emulating the GUI. It's also extensive, free, open-source and mature. Why not give it a try, like many others have? »

The Fast, Light Toolkit (FLTK, pronounced fulltick) is a cross-platform graphical user interface (GUI) library developed by Bill Spitzak and others. Made to accommodate 3D graphics programming, it has an interface to OpenGL, but it is also suitable for general GUI programming.

The FOX toolkit is an open source, cross-platform widget toolkit, that is, a library of basic elements for building a graphical user interface (GUI).