Girder!

EventGhost is an advanced, easy to use and extensible automation tool for MS Windows. It can use different input devices like infrared or wireless remote controls to trigger macros, that on their part control a computer and its attached hardware. So it can be used to control a Media-PC with a normal consumer remote. But its possible uses go much beyond this.

The most powerful remote control solution for the Mac®. Control more than 100 applications, virtual keyboard and mouse, presentations, media center software and important system settings right from your iPhone™, iPod® Touch, your Apple® Remote or one of the many other remote controls supported by Remote Buddy!

Intelliremote is a software program that gives you complete remote control of your Home Theater PC infrared or radio frequency remote and unlocks its true potential. HTPC makers have an excellent idea bundling an IR or RF remote control with their product...it's just too bad the software included doesn't do everything you want your remote to do!

HomeSeer presents a revolutionary approach to home automation. HomeSeer's home automation software and hardware solutions make your life more comfortable, convenient, safe and secure. Control your lighting, thermostats, security system, blinds and shades, whole home music, and entertainment center from anywhere in the world