Gimp Paint Studio!

Krita is a complete creative sketching and painting application with advanced, commercial quality features. It's free, open-source and available across all major desktop platforms.

MyPaint is a fast painting program with an emphasis on full-screen use. It lets you focus on the art instead of the program. You work on your canvas with minimum distractions, bringing up the interface only when you need it. MyPaint supports pressure or tilt sensitive graphic tablets and comes with an easy-to-use brush collection. There is a complex interface for creating own brushes, focusing on brush dynamics (changes with speed, pressure, randomly).

Clip Studio Paint, previously Manga Studio or ComicStudio in Japan, is a family of software applications for Mac OS X and Microsoft Windows used for the digital creation of comics and manga.

Get ready to take your photos where no photo has gone before with Fotor.

Seashore is an open source image editor for Mac OS Xs Cocoa framework. It features gradients, textures and anti-aliasing for both text and brush strokes. It supports multiple layers and alpha channel editing. It is based around the GIMPs technology and uses the same native file format.

Artweaver is a simple Freeware program for creative painting, i.e. Artweaver offers you all artistic effects which you need for your work.

Corel Painter is a raster-based digital art application created to simulate as accurately as possible the appearance and behavior of traditional media associated with drawing, painting, and printmaking. It is intended to be used in real-time by professional digital artists as a functional creative tool.

Sumo Paint is a powerful image editor with a long-standing history as a fully capable Photoshop clone in the browser. Being designed for the browser, it's accessible on practically any system and loads much faster than most comparable desktop tools while still providing core commercial features like layer-based editing with layer effects, multiple built-in filter effects and color adjustment tools.

A simple but lovely natural media painting and sketching program. Art oriented, but capable of loading/saving photoshop files. A very cheap alternative to Painter, with a stripped down, elegant interface.

Drawpile is a drawing program that lets you share the canvas with other users in real time.